Optical tomography is a form of computed tomography that creates a digital volumetric model of an object by reconstructing images made from light transmitted and scattered through an object. Introduction diffuse optical tomography dot 1, 9 is a method of imaging technique using nearinfrared nir region for biomedical applications that has potential to provide the threedimensional images of the optical parameters such as absorption coefficient and the scattering coefficient 12, 16. The approach is capable of reconstructing the quantitative optical parameters absorption coefficient and scattering coefficient of a soft tissue. Written by an authority involved in the field since its nascent stages, diffuse optical tomography. Dec 19, 2017 diffuse optical tomography dot is a noninvasive technique that uses nearinfrared nir light to map tissue optical properties. Diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased reconstruction algorithms using nir measurements along or near the boundary of tissue. Dot has inherently low spatial resolution due to diffuse nature of photons. Diffuse optical tomography dot and imaging doi are noninvasive techniques that utilize light in the near infrared spectral region to measure the optical properties of physiological tissue. We propose two new reconstruction algorithms which so far have not been applied to such a situation and compare their performances in certain. However, current continuouswave dot requires highdensity probe arrays for measurement less than 15mm interval to gather enough information for 3d image reconstruction, which makes the experiment timeconsuming. Sparsity and level set regularization for diffuse optical tomography using a transport model in 2d. Rajendra kumar school of medical science and technology, indian institute of technology kharagpur.
With dot, 3d images of the optical properties are reconstructed from boundary measurements, and this could enable a quantitative determination of regional cerebral hb details fig. Diffuse optical tomography by huabei jiang waterstones. Atlasbased head modeling and spatial normalization for. The motivation for reconstructing the optical property variation is that it and, in particular, the. Diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased reconstruction algorithms using nir measurements along. Chromophore concentrations and diffusion amplitude are recovered using a linearized born approximation model and. Diffuse optical tomography using semiautomated coregistered. Sep 03, 2018 written by an authority involved in the field since its nascent stages, diffuse optical tomography. We explore the use of diffuse optical tomography dot for the recovery of 3d tubular shapes representing vascular structures in breast tissue. Huabei jiang based on near infrared optical technologies and modelbased inverse computations, dot is an imaging method that can provide spatial distributions of intrinsic tissue optical properties through. Atlasbased head modeling and spatial normalization for high.
Reconstructions for continuouswave diffuse optical. Recent developments in highdensity diffuse optical tomography hd dot overcome previous limitations of sparse doi systems, providing. Imaging the body with diffuse optical tomography ieee. Optical tomography an overview sciencedirect topics. Diffuse optical tomography principles and applications. Use features like bookmarks, note taking and highlighting while reading diffuse optical tomography. But, unlike xrays, which use ionizing radiation, optical imaging uses visible light and the special properties of photons to obtain detailed images of organs and tissues as well as smaller structures including cells and even molecules. October 7, 2009 mathematical solutions to enhance the image quality of diffuse optical tomography dot to use for breast cancer screening is in development at clemson university in collaboration with researchers at the university of bremen, germany. Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia j cereb blood flow metab 23. Diffuse optical tomography dot is based on diffuse light that penetrates tissue at multiple projections yielding tomographic images. The patient was placed in prone position on the scanner bed with one breast suspended in a sizematched cup the scanning unit of the dot system consists of a cup with a total of 507 optical fibers mounted on the surface. This technique has been applied for oncology and brain imaging. Huabei jiang based on near infrared optical technologies and modelbased inverse computations, dot is an imaging method that can provide spatial distributions of intrinsic. Diffuse optical tomography dot is one of the emerging modalities for the noninvasive imaging of thick biological tissues using nearinfrared nir light.
Diffuse optical tomography with a priori anatomical. Diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased reconstruction. Motivation if you shine a flashlight onto your hand, you can clearly see that light can travel through a few centimeters of tissue and still be detected. Diffuse optical tomography enhanced by clustered sparsity for functional brain imaging abstract. Because water absorption in the nir spectrum is low, the light can penetrate several centimeters inside soft tissue, for example, breast and brain. Diffuse optical tomography dot modeling and reconstruction m. Due to the nature of light propagation in the tissue, the reconstruction problem is severely illposed. Imaging the body with diffuse optical tomography abstract. Download it once and read it on your kindle device, pc, phones or tablets. Sep 03, 2018 diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased reconstruction algorithms using nir measurements along or near the boundary of tissue. Optical mammography is a new application of dot 4 6.
Jacob, image reconstruction for diffuse optical tomography using sparsity regularization and expectationmaximization algorithm, optics express, 15 2007, 695708. The techniques rely on the object under study being at least partially lighttransmitting or translucent, so it works best on soft tissues such as. Diffuse optical tomography dot is a noninvasive, nonionizing, and inexpensive imaging technique that uses nearinfrared light to probe tissue optical properties. Diffuse optical tomography how is diffuse optical tomography abbreviated. However, we are very confident that the important ingredients of a realistic transport model for 3d diffuse optical tomography are wellrepresented in our 2d model, and that the use of a more. Diffuse optical tomography dot scans were performed on an experimental dot system figure 1. Diffuse optical tomography dot is an advanced imaging method used to visualize the internal state of biological tissues as 3d images. Nov 17, 2019 diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased reconstruction algorithms using nir measurements along or near the boundary of tissue. Journal of applied mathematics and physics, 2, 2042. Aug 01, 2019 diffuse optical tomography of the breast. Models and algorithms for diffuse optical tomographic system. Regional variations in oxy and deoxyhemoglobin concentrations as well as blood flow and oxygen consumption can be imaged by monitoring spatiotemporal variations in the absorption. Developing highdensity diffuse optical tomography for. Diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents.
Diffuse optical tomography dot using nearinfrared nir light is a promising tool for noninvasive imaging of deep tissue. Forward model analysis in diffuse optical tomography using. Using a parametric level set method pals our method incorporates the connectedness of vascular structures in breast tissue to reconstruct shape and absorption values from severely limited data sets. Principles and applications is a longawaited profile of a revolutionary imaging method. Diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased. Recent developments in highdensity diffuse optical tomography hd dot overcome previous limitations of sparse doi systems, providing improved image quality and brain specificity. Diffuse optical tomography enhanced by clustered sparsity.
Dec 03, 2012 diffuse optical tomography dot modeling and reconstruction m. Diffuse optical tomography dot is a noninvasive technique that uses nearinfrared nir light to map tissue optical properties. Integrated diffuse optical tomography and photoacoustic. Optical tomography is used mostly in medical imaging research. Diffuse optical spectroscopy dos is applied to the local measurement of the optical properties of scattering media, whereas diffuse optical imaging doi and diffuse optical tomography dot are used to characterize or image the spatial distribution of the properties. Diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased reconstruction algorithms using nir. In dot, light is guided by the fiber optics to the surface of the subject e. The diffuse optical tomography dot is a new modality for biomedical imaging 1 3. The tutorials introduce the concept of the forward and inverse problems in. The authors present the design and evaluation of a secondgeneration g2 hybrid photoacoustic tomography pat and diffuse optical tomography dot imaging system for detection of breast cancer. Below is a list of online tutorials shows typical use examples for the matlabtoast toolbox. Diffuse optical imaging doi is a method of imaging using nearinfrared spectroscopy nirs or fluorescencebased methods.
Sparsity and level set regularization for diffuse optical. Diffuse optical tomography dot is a noninvasive imaging technique to detect the presence of a tumor or other anomalies in human tissues. Optical tomography in industry is used as a sensor of thickness and internal structure of. The tutorials introduce the concept of the forward and inverse problems in optical tomography step by step. When used to create 3d volumetric models of the imaged material doi is referred to as diffuse optical tomography, whereas 2d imaging methods are classified as diffuse optical topography. Despite the practical value of dot, many engineers from electrical or applied mathematics backgrounds do. In our lab, we develop di use optical tomography dot, which is a more advanced method of performing optical imaging. Learnable douglasrachford iteration and its applications. Dot is a noninvasive and safe method that can be considered as a functional imaging method 3.
The authors present the design and evaluation of a secondgeneration g2 hybrid photoacoustic tomography pat and diffuse optical tomography dot imaging system for. Each tutorial contains a link to the matlab script to recreate the example. Diffuse optical tomography dot is an ongoing medical imaging modality in which tissue is illuminated by nearinfrared light from an array of sources, the multiplyscattered light which emerges is observed with an array of detectors, and then a model of the propagation physics is used. Diffuse optical tomography dot to use for breast cancer screening. Optical tomography in industry is used as a sensor of thickness and internal structure of semiconductors.
Dot uses arrays of lasers and detectors in multiple geometric configurations around the object. My research has been to pioneer the in vivo use of dot. Because water absorption in the nir spectrum is low, the light can penetrate several centimeters. Three dimensional optical tomographic brai n imaging in small animals, part 2. Optical imaging is a technique for noninvasively looking inside the body, as is done with xrays. A parametric level set method pals is implemented for image reconstruction for hyperspectral diffuse optical tomography dot. Diffuse optical tomography dot is a very promising approach to further a resolution of the aforementioned issues. Diffuse optical tomography dot is an ongoing medical imaging modality in which tissue is illuminated by nearinfrared light from an array of sources, the multiplyscattered light which emerges is observed with an array of detectors, and then a model of the propagation physics is used to infer the localized optical properties of the illuminated tissue. In this study, we intend to use diffuse optical tomography dot as a non invasive, safe and low cost technique that can be considered as a functional imaging method and mention the importance of image reconstruction in accuracy and procession of image. Principles and applications kindle edition by huabei jiang. Diffuse optical tomography dot provides spatial distributions of intrinsic.
Diffuse optical imaging doi is increasingly becoming a valuable neuroimaging tool when fmri is precluded. The techniques rely on the object under study being at least partially lighttransmitting or translucent, so it works best on soft tissues such as breast and brain tissue. Osa diffuse optical tomography using multidirectional. Diffuse optical imaging is a functional medical imaging modality which takes advantage of the relatively low attenuation of nearinfrared light to probe the internal optical properties of tissue. Diffuse optical tomography dot deals with 3d reconstruction of optical properties of tissue given the measurements and a forward model of photon propagation. Diffuse optical tomography dot provides spatial distributions written by an authority involved in the field since its nascent stages, diffuse optical tomography. Math may connect the dots in diffuse optical tomography. Diffuse optical tomography dot is a noninvasive technique which measures hemodynamic changes in the tissue with near infrared light, which has been increasingly used to study brain functions. However, early optical systems had poor imaging performance, and the momentum for the technique slowed. For linearized dot problems, sparsity regularization has achieved. Diffuse optical tomography enhanced by clustered sparsity for. Parametric estimation of 3d tubular structures for diffuse. Diffuse neurofibrillary tangles with calcification. In this paper we address an inverse problem for the timedependent linear transport equation or radiative transfer equation in 2d having in mind applications in diffuse optical tomography dot.
972 1337 953 1102 1387 446 267 119 990 125 137 1304 517 1221 1463 984 1308 975 521 133 1074 166 490 803 1092 802 403 1379 1414 781 247 1299 76 829 697 1474 124 975 397 906 936 353 718